Trifluoperazine inhibits the incorporation of labelled precursors into lipids, proteins and DNA ofMycobacterium tuberculosisH37Rv

Incorporation of spin-labelled amino acids into proteins.

The elucidation of structure and function of proteins and membrane proteins by EPR spectroscopy has become increasingly important in recent years as technological advances have been made in the design of spectrometers and in the chemistry of the nitroxide group. These new developments have increased the demand for tailor-made amino acids carrying a spin label on the one hand and for reliable me...

Incorporation of 14C-labelled fatty acids into the mammary-gland lipids of the lactating rabbit.

1. [1-(14)C]Stearic acid, [9-(14)C]stearic acid, [9-(14)C]palmitic acid and [9-(14)C]decanoic acid were fed to lactating rabbits, and the fatty acids of the mammary gland were separated and partially degraded. 2. Most of the (14)C recovered was located in the acids fed. Stearic acid was least efficiently absorbed; decanoic acid was the most extensively metabolized. 3. Resynthesis after degradat...

The incorporation of labelled phosphate into the lipids of a brain dispersion.

Biosynthesis of aurodox (antibiotic X-5108). incorporation of 14C-labelled precursors into aurodox.

Streptomyces go/diniensis produces aurodox 3) (1) and small amounts of its N-demethyl homolog mocimycin (2)4) which is probably identical 5) with kirromycin 6,7). These antibiotics and a recently discovered disaccharide derivative of aurodox (3)8) are primarily active against Grampositive bacteria and enhance the growth of farm animals. The chemical structures, including stereochemistry, have b...

Trifluoperazine Inhibits the Contraction

A B S T R A C T Cultured, spontaneously beating heart cells were used to study the role of calmodulin in regulating cardiac contraction. Trifluoperazine (TFP), an antipsychotic drug that binds to calmodulin, reversibly inhibited myocardial contraction. This effect occurred over a TFP concentration range of 5-100 MM with half maximal activity at -15 uM TFP. When the phosphoprotein profile of TFP...